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Reviewed by Dr. Patricia Tejedor · Updated: October 23, 2026
Rectal cancer

Watch and wait: when rectal cancer surgery can be avoided

If the tumor disappears completely after chemotherapy and radiotherapy, some patients can keep their rectum without surgery up front, under very close follow-up.

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Clinical summary

Watch and wait is considered in rectal cancer when, after radiotherapy and chemotherapy, no tumor can be seen on examination, endoscopy or MRI. Immediate surgery is avoided and check-ups are done every 3 months. If the tumor comes back, it is operated on, and in most cases that surgery is still possible and effective.

What is watch and wait?

For years, treatment of rectal cancer always ended in the operating room. Today most patients first receive radiotherapy and chemotherapy to shrink the tumor, and in some of them the tumor disappears completely. This is called a clinical complete response.

These patients can be offered an alternative to immediate surgery: watching the rectum closely with frequent check-ups and operating only if the tumor comes back. This is known as watch and wait, rectal preservation or active surveillance. The aim is to keep the rectum and avoid major surgery when it is not needed.

Watch and wait does not mean stopping treatment. The treatment has been given, and what changes is that surgery is kept for those who need it.

How the decision is reached

The process follows the same steps as any rectal cancer until the response to the initial treatment is assessed.

1. Diagnosis and staging

Colonoscopy with biopsy, CT scan, pelvic MRI and blood tests with tumor markers to find out how far the tumor has spread.

2. Initial treatment (TNT)

Radiotherapy, with or without chemotherapy, and systemic chemotherapy. In most cases it lasts several weeks or months.

3. Response assessment

The rectum is checked with clinical examination, endoscopy and MRI to see whether any tumor remains.

4. Surgery or watch and wait

If tumor remains, surgery is performed, aiming to preserve the sphincter. If the response is complete, close follow-up without immediate surgery is an option.

Infographic in Spanish showing rectal cancer treatment in five steps: diagnosis, initial TNT treatment, response assessment, surgery or watch and wait, and follow-up
Rectal cancer treatment, from the first visit to follow-up (infographic in Spanish).

Which patients can be candidates?

It is only considered in selected cases. The tumor must have responded completely to treatment and the tests must show no disease. The patient also has to be able to stick to strict follow-up, because check-ups are frequent and cannot be skipped.

The decision is made by a multidisciplinary board with experience in this strategy, made up of colorectal surgeons, oncologists, radiologists and gastroenterologists. Reading the MRI and endoscopy correctly after chemotherapy and/or radiotherapy is what makes selection safe, which is why the assessment should be done by a team that treats rectal cancer routinely.

Benefits and risks

What you gain

The rectum and bowel function are kept, major surgery is avoided and so is the stoma. For many patients this means a better quality of life.

What the risk is

The main risk is that the tumor comes back during follow-up. That is why check-ups are so close: if it returns, it is detected early and operated on promptly.

If surgery is needed after all

In most cases surgery is still possible and effective. Whenever possible it is done robotically, also after radiotherapy.

What follow-up involves

Check-ups include clinical examination with digital rectal exam, rectoscopy (rigid or flexible), pelvic MRI, a CT scan of the chest, abdomen and pelvis, and tumor markers in the blood. As a guide, they are every 3 months for the first 2 years and every 6 months until 5 years are completed, although the schedule is adjusted to each patient. It is more intensive than the follow-up after conventional surgery, and it is what allows action in time if the tumor grows back.

If the tumor reappears in the rectum during that time, surgery is scheduled. Detecting it early allows salvage surgery with curative intent in a high percentage of cases. If it does not, the patient keeps their rectum.

Rectal preservation specialists

Colorectal surgeons of the team at Hospital Memorial Publio Cordón.

Prof. Julio García Aguilar

Prof. Julio García Aguilar

Colorectal surgeon

View doctor: Prof. Julio García Aguilar
Chief of the Colorectal Service at Memorial Sloan Kettering Cancer Center, principal investigator of the OPRA trial on organ preservation and total neoadjuvant therapy (TNT) in rectal cancer.

Frequently asked questions about watch and wait

Does watch and wait mean stopping cancer treatment?

No. The patient has already received radiotherapy and chemotherapy, and the tumor has disappeared with that treatment. What we do is adapt the treatment to preserve the rectum and quality of life, keeping oncological safety through frequent check-ups.

What happens if the tumor grows back?

It is operated on. Because check-ups are frequent, regrowth is detected early, and in most cases surgery is still possible and effective.

How often are the check-ups and what do they include?

As a guide, every 3 months for the first 2 years and every 6 months until 5 years are completed. They include clinical examination with digital rectal exam, rectoscopy, pelvic MRI, CT scan and tumor markers. It is more intensive than follow-up after conventional surgery.

Can I ask for it if I have been told I will need a stoma?

It depends on how the tumor responds to the initial treatment. If the response is complete and the board considers it safe, watch and wait avoids surgery and the stoma with it. If tumor remains, surgery will be performed, always aiming to preserve the sphincter when possible.

Can robotic surgery be done after radiotherapy?

Yes. If surgery is needed during follow-up, the robotic approach is preferred whenever possible, also after previous treatments. The robot gives more precision in the pelvis and helps preserve the nerves.

Can I get a second opinion to find out if I am a candidate?

Yes. We review your tests and the report of the treatment you received and tell you whether watch and wait is an option in your case. You can do it in person in Madrid or through our online second opinion.

Where to treat rectal cancer?

We operate in two private hospitals in Spain. The same medical team treats you in Madrid and in Barcelona, with the same surgical and oncological protocols.

Memorial Publio Cordón Hospital, Madrid
Madrid

Memorial Publio Cordón Hospital

Private hospital in Pozuelo de Alarcón with a multidisciplinary team specialised in digestive surgical oncology.

Paseo de la Casa de Campo, 5 28223 Pozuelo de Alarcón, Madrid
View Memorial Publio Cordón Hospital
Centro Médico Teknon, Barcelona
Barcelona

Centro Médico Teknon

Private hospital in Barcelona where the team performs high-complexity surgical oncology.

Carrer de Vilana, 12 08022 Barcelona
View Centro Médico Teknon

Patients treated by the Quenet Torrent team

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